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Thursday, February 6, 2020 | History

6 edition of Genetic variants and strains of the laboratory mouse found in the catalog.

Genetic variants and strains of the laboratory mouse

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  • 37 Currently reading

Published by Oxford University Press, G. Fischer Verlag in Oxford [England], New York, Stuttgart .
Written in English

    Subjects:
  • Mice -- Genetics,
  • Mice -- Variation,
  • Mice as laboratory animals,
  • Mammals -- Genetics,
  • Mammals -- Variation

  • Edition Notes

    Includes bibliographical references.

    Statementedited by Mary F. Lyon and Antony G. Searle for the International Committee on Standardized Genetic Nomenclature for Mice.
    ContributionsLyon, Mary F., Searle, Antony G., International Committee on Standardized Genetic Nomenclature for Mice.
    Classifications
    LC ClassificationsQL737.R638 G45 1989
    The Physical Object
    Paginationxiii, 876 p. :
    Number of Pages876
    ID Numbers
    Open LibraryOL2060436M
    ISBN 100198542046
    LC Control Number88039796

    Moreover, the study found that the pedigrees of the 15 mouse strains studied are not what they were previously assumed to be. As discussed earlier, it is always preferable to use a fertile stud male with the same genotype as the female, whether it is inbred or an F1 hybrid. Mamm Genome 9 1 : 1. The mutations induced by X-rays are often large-scale genomic alterations including translocations, inversions, and deletions.

    Funding for this research has been controversial as a result of safety concerns, and has been halted at times. First, its average litter size of 9. One should realize that the most common effect of any undirected mutagen will be to "knock-out" a gene and, in the vast majority of cases, the resulting null allele will be recessive to the wild-type. Origins and characteristics of inbred strains of mice ; The Nomenclature Committee formed the Editorial Board. Most often, gene targeting is used to generate a mutation such that the gene no longer produces a functional product a null allele of the gene.

    In a congenic, the variant as well as the contiguous genes from the first strain near the variant are brought into the background since recombination will not efficiently remove closely linked DNA. Both of these chemicals produce much higher yields of mutations than any form of radiation treatment tested to date Russell et al. Rederivation is an embryo transfer where the embryo donor mother is kept in quarantine, the embryos recovered sterilely and transported out of quarantine and transferred into a Specific Pathogen-Free pseudopregnant recipient female, housed in a facility which is Specific Pathogen-Free. A First, a targeting vector is constructed which contains the cassette to be introduced engineered cassette flanked both upstream and downstream with DNA sequences that match perfectly i. Genotyping is most often performed at weaning.


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Genetic variants and strains of the laboratory mouse Download PDF Ebook

This study also showed that CHL-induced mutations were often associated with reciprocal translocations. Continued backcrosses to this strain generates subsequent backcross generations N2, N3 etc. The rationale for these studies is the belief that many although not all genes can be Genetic variants and strains of the laboratory mouse book phenotypically by knock-out mutations which are bred to be doubly heterozygous with a deletion.

First, the methodology required for simply knocking-out a gene is more straightforward and better developed at the time of this writing than the hit-and-run methodology. A second consideration is whether the investigator will be able to distinguish natural-born pups from those that have been fostered.

Systems for temporal control of transgene expression also exist. A valuable source of diverse-looking mouse populations were breeders of "fancy mice," a popular hobby in Victorian and Edwardian England and America as well as for centuries in Asia.

In a splice acceptor trap, when the gene trap inserts into an intron in the correct orientation, the endogenous gene's splicing pattern is disrupted by splicing into the splice acceptor of the gene trap.

Sterile males can be derived genetically or surgically. The seven loci chosen to be followed in the specific locus test were defined by recessive mutations with visible homozygous phenotypes that were easily distinguished in isolation from each other, and had no effect on viability or fertility.

Typically, these systems involve two transgenes, one which expresses a transcription factor which binds to the drug which activates or inhibits the transcription factor; the second has DNA sequences for binding of the transcription factor which regulate expression of the target sequences in cis.

Rather than attempt to examine all animals for all effects of a particular irradiation protocol as was common in earlier experimentsthese mouse geneticists chose instead to look only at the small fraction of animals that were mutated at a small set of well-defined "specific" loci.

F1 mice are more robust than their parents due to hybrid vigor. Mouse strains can be inbredmutatedor genetically engineeredwhile rat strains are usually inbred.

Mouse News Letter

Muriel Davisson Davisson, For the first time, JAX will be importing mice from large numbers of individual researchers. Plants[ edit ] The term has no official ranking status in botany; the term refers to the collective descendants produced from a common ancestor that share a uniform morphological or physiological character.

What is a laboratory mouse?

Coisogenic mice have a variant mutation, transgene, targeted allele which Genetic variants and strains of the laboratory mouse book directly on that strain. The reason for such strain-specific differences is that some chromosomal regions are normally maintained in chromatin configurations that can act to suppress gene activity.

Finally, the fraction of injected embryos that survive into live born animals is also much greater than that observed with all other inbred strains. Unfortunately, this approach would require the generation of a separate endogenous clone for each and every transgenic line to be studied.

The nonagouti gene product is necessary for the production of the yellow pigment, so mutant nonagouti mice have black hair. This observation is usually a good indication that the transgene has disrupted the function of an endogenous locus through the process of integration.

In albino mutants, neither pigment is made.Sorry, our data provider has not provided any external links therefore we are unable to provide a link to the full galisend.com: M S Deol. Jul 30,  · Scientists have found that the genetic variation in the most widely used strains of laboratory mice is vastly greater than previously thought.

The research could have major implications for. Aug 01,  · The Mouse Genomes Project is an ongoing collaborative effort to sequence the genomes of the common laboratory mouse strains.

Inthe initial analysis of sequence variation across 17 strains found M unique single nucleotide polymorphisms (SNPs) and M indels. We carry out deep sequencing of 13 additional inbred strains (BUB/BnJ, C57BL/10J, C57BR/cdJ, C58/J, DBA/1J, Cited by: Mtdna Phytogeny and Evolution of Laboratory Mouse Strains.

heteroplasmic mice with mtDNAs from variants characteristic of. because degeneracy of the genetic code.Full text Full text is available as a scanned copy of the original print version.

Get a printable copy (PDF file) of the complete article (K), or click on a page image below to browse page by galisend.com: Robin Winter.Theor.

Appl. Genet. 62 () Green, M.C.: Genetic Variants and Strains of the Ebook Mouse. Stuttgart, New York: G. Fischer Ebook pp., 7 figs. Hard bound DM This book provides the reader with an up-to-date catalog of genetic material of the laboratory mouse available at the main breeding centers to researchers in the biological and medical sciences.

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